Best Western Key Ambassador Resort Inn welcomes two dogs up to 80 lbs for an additional fee of $25 per night (not to exceed $150 per stay). Guests traveling with dogs must book rooms with "Pet Friendly" in the description or risk not being able to check in with a dog and/or incurring any associated cancellation penalties. Cats are not permitted.

Margaritaville Key West Resort & Marina accepts two dogs up to 45 lbs for an additional fee of $75 per dog, per night. Dogs may not be left unattended in rooms. Cats and other pets are not permitted.

DoubleTree Resort Grand Key welcomes two pets up to 75 lbs for an additional fee of $75 per stay. All rooms are pet friendly.

Hyatt Key West Resort and Spa welcomes two dogs up to 50 lbs for an additional fee of $150 (for stays of 1 to 6 nights) and $300 (for stays of 7 nights or more). All rooms are dog friendly. Cats are not permitted.