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221 Main is a restaurant and cocktail bar in St. Joseph, MO with pet-friendly patio. Photo by 221 Main Restaurant and Cocktail House.
221 Main is a restaurant and cocktail bar in St. Joseph, MO with pet-friendly patio. Photo by 221 Main Restaurant and Cocktail House.
221 Main is a restaurant and cocktail bar in St. Joseph, MO with pet-friendly patio. Photo by 221 Main Restaurant and Cocktail House.
221 Main is a restaurant and cocktail bar in St. Joseph, MO with pet-friendly patio. Photo by 221 Main Restaurant and Cocktail House.
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221 Main Restaurant and Cocktail House

221 Main is a restaurant and cocktail bar in St. Joseph, MO with a large, pet-friendly patio. The menu includes ribeye, filet mignon and slow-roasted prime rib served every Friday & Saturday. They also feature hand-crafted cocktails, a large craft beer selection, and wine from local and world wineries. Reservations, especially on weekends, are strongly encouraged. Visit Website

Or call (269) 982-4000 or email 221reservations@gmail.com for more information.

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221 Main Restaurant and Cocktail House is rated 4.0 stars out of 5 by 188 guests on TripAdvisor. Be the first to on BringFido!

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